Idiopathic inflammatory myopathies associated with PM-ScL antibodies: about a clinical case

Abstract

Idiopathic inflammatory myopathies (IIM) are a group of immune-mediated diseases that mainly affect skeletal muscles and very often other organs and systems. Occasionally they overlap with other autoimmune diseases (AID), mainly systemic sclerosis (SS). The clinical phenotype in IIM is associated with the autoanti- body profile. Anti-PM-Scl antibodies have been classified as IIM- associated abs, since they can be found in other AID, mainly SS. The clinical manifestations or phenotype associated with PM-Scl abs are a "spectrum" that includes manifestations of SS and IIM. This overlapping phenotype between both entities has been called “Scleromyositis”. A case representing this clinical phenotype is presented here.